The nitric oxide (NO) sports supplement category has grown to astronomical proportions in recent years, although this is really a “pre-workout” supplement category with NO-associated compounds comprising a minority percentage of the ingredients in the more popular supplement formulations. Although everyone in the sports supplement world is talking about NO, very few people really understand much about it. When the amino acid L-arginine is delivered to the endothelial cells of the inner layer of arterial walls, nitric oxide (NO) is formed via the enzyme nitric oxide synthase (NOS), which means that L-arginine is a precursor of NO. Increased levels of NO cause vasodilation (widening) of blood vessels. This leads to increased blood volume (known in the bodybuilding world as “the pump”), which is sought after by bodybuilders to optimize the grueling exchange of oxygen, glucose, amino acids, creatine, waste byproducts of muscular contraction, etc., that takes place both into and out of muscle during and immediately after intense muscular contraction. It might seem logical to conclude that supplementing with L-arginine would enhance the production of NO. However, it’s more complicated than that. The body uses L-arginine for many purposes other than its role as a precursor of NO. Also, according to the PDR® for Nutritional Supplements™, in vitro studies have shown that under normal physiological circumstances NOS is saturated with its L-arginine substrate. In other words, L-arginine would not be expected to be rate limiting for the NOS enzyme, and it would not appear that supra physiological levels of L-arginine-which would occur with oral supplementation of L-arginine-would make any difference with regard to NO production. The reaction would appear to have reached its maximum level. However, in vivo studies have demonstrated that under certain physiological conditions, supplemental L-arginine can enhance endothelial-dependant vasodilation and NO production, possibly through mechanisms that interfere with compounds that are normally inhibitors of NOS. This discordance between the in vitro and in vivo results is known as the “arginine paradox”. Scientific data has not yet validated that intense muscular contraction fosters a type of physiological environment that enables supplemental L-arginine to positively influence greater activity of NOS and thus enhanced levels of NO. Despite this lack of scientific support, “real-world” anecdotal evidence, from the stomping grounds in the gyms across America, suggests that NO supplements are contributing to enhanced levels of NO. However, because the formulations in these popular NO products contain many beneficial pre-workout compounds (mostly creatine and other amino acids) that are unrelated to the production of NO, one cannot discount the extent to which these other compounds may be contributing to the vasodilation effect that has already been initiated by the body in response to intense muscular contraction.
For a moment, let’s operate under the assumption that the physiological state resulting from the onset of intense muscular contraction does tip the balance of the “arginine paradox” scale in favor of L-arginine enhanced NOS activity and NO production. The entire sports supplement industry, in its near insane NO craze, has still completely missed the boat when it comes to creating the best possible NO products, because these product formulations fail to utilize L-arginine effectively to push the real boundaries of NO production. L-arginine is easily broken down by the enzyme arginase before it can be made available to endothelial cells, which has led other supplement companies to use an “end run” approach–to bypass arginase by utilizing a precursor of L-arginine called L-arginine alpha-keto-glutarate (AAKG). Unfortunately, this now brings an intermediary compound(s) into the “food chain” of NO production, which may very well result in gross inefficiency in terms of supplying optimal levels of L-arginine to the endothelial cells for NO production. Hi-Tech Pharmaceuticals, on the other hand, utilizes a “straight up the middle” approach by blasting high dosages of L-arginine into the bloodstream along with highly potent, arginase inhibitors that bond to arginase enzymes, which render these enzymes incapable of preventing L-arginine from uniting with NOS enzymes on their way to creating NO. This is a very novel pathway to NO production, which Hi-Tech employs in its N.O. Overload™ Muscle & Strength supplement (and also in Anavar®).
Nitric oxide (NO) sports nutrition has become the largest sports nutrition product category. Yet, despite dozens of “advancements” in NO supplementation, traditional NO sports nutrition still remains flawed for one fundamental reason. This flaw can easily be detected by simply inspecting the formulations in NO products across-the-board throughout the sports nutrition industry. The formulations in these products demonstrate a failure on the part of other supplement companies to understand and address the most efficacious means to serve L-arginine up on a platter for the production of NO, which is to incapacitate the arginase enzyme. Arginase is the enzyme that breaks down arginine, which is a problem for NO supplements because arginine is the source of NO production. With the exception of Hi-Tech Pharmaceuticals, no other supplement company has figured out how to tackle the arginase problem head-on… to take arginase out of the NO equation!
In discovery, science often finds purpose. Many novel scientific discoveries have been encountered while in search of unrelated applications. Hi-Tech initially developed 2(S)-amino-6-boronhexanoic acid (ABH) and S-(2-boronethyl)-L-cysteine HCl (BEC) as sexual stimulants when perfecting its formulation for Stamina-Rx®, only to discover that these compounds had amazing muscle-building properties. Hi-Tech utilizes ABH and BEC, the novel arginase inhibitors in ,N.O. Overload™ to flank the high dosage of L-arginine and to take arginase head-on by rendering it useless. This leaves an abundance of L-arginine uncompromised in the muscle pool to create a wealth of NO, leading to maximum muscular vasodilation. But that’s only the beginning…
N.O. Overload™ is exactly what its name says it is…an overload of NO! But that’s only the beginning. N.O. Overload™ is jacked with over 30 ingredients that include three arginase inhibitors, nine muscle cell volumizing and work performance technology compounds, five NO drivers with Micro-Rx™ and Extend-Rx™ Technology, six energy complex components, and four amino acid recovery agents. N.O. Overload™ is designed to take advantage of the pre-workout window of opportunity to accelerate muscle growth by creating a feeding pool flourishing with compounds that improve training intensity, work performance, and set your muscles up for more rapid recovery and enhanced muscular growth. N.O. Overload™ empowers your muscles (throughout your entire training session) not only with the very best that sports supplement science has to offer in utilizing the potential benefits of increased NO production, but also blasts your system with the very best pre-workout compounds known to nutraceutical sports science to create the most dynamic muscle-building environment imaginable!
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to treat, cure, diagnose, or prevent any disease. This product should not be used in place of or as a substitute for recommendations by your healthcare professional. No clinical study has been performed on N.O. Overload™. These statements are based on the active ingredients: L-arginine, L-arginine AKG, BEC, ABH, L-norvaline, Creatine Monohydrate, ATP, COP, L-taurine, Caffeine, Theobromine, Acacia rigidula, Beta alanine, L-Leucine, L-isoleucine, L-valine, L-glutamine.